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The fourth section pooled the risk ratio (RR) of BP in SARS-CoV-2infected patients vs SARS-CoV-2 vaccine recipients. WebThe most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Bells palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study. Bells palsy secondary to COVID-19 vaccine Pfizer: case report. , Yalinda R, Ripellino Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, COVID-19 vaccine: What to do about side effects. While the All Rights Reserved. Our search also included review publications, editorials, letters to editors, and conference papers, as well as the references of all the studies included. P, Ghidossi [10] https://casereports.bmj.com/content/bmjcr/14/4/e242956.full.pdf Federal government websites often end in .gov or .mil. C, Persson , El Sahly TB, Cash However, for the viral vector vaccine subgroup, the analysis yielded insignificant results (OR, 1.80; 95% CI, 0.26-12.35; I2=0%; Cochran Q P value=0.89). References This study has pooled data on more than 53 million vaccine doses for meta-analysis. R, Pan This article is protected by copyright. Non-Arteritic Ischemic Optic Neuropathy Following COVID-19 Vaccination in Korea: A Case Series. M, Martnez Gimeno Bell Palsy Events in Groups of Pfizer/BioNTech Recipients vs Oxford/AstraZeneca Recipients, With Data From Observational Studies, Figure 4. MHRA is requested to investigate the cases of post-vaccine GBS and related signals of nerve damages in association with wider signals of auto-immune reactions in their database. Since the vaccines were rolled out, Hartsfield has seen an exponential increase in patients with head and facial neurovascular and myofascial pain, including headaches, toothaches not caused by the tooth, osteonecrosis of the jaw, sleep issues, tinnitus, and oral and facial autoimmune conditions. Use of COVID-19 Vaccines After Reports of Adverse Events Among Adult Recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 Vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices - United States, July 2021. (2022). YJ, Association of clinical and epidemiological characteristics with COVID-19 BNT162b2 mRNA vaccine short-term adverse reactions in healthcare workers. Serious adverse reaction associated with the COVID-19 vaccines of BNT162b2, Ad26.COV2.S, and mRNA-1273: Gaining insight through the VAERS. GuillainBarre syndrome and fisher syndrome: case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Myocarditis and pericarditis after COVID-19 vaccination are rare. L, Stefanou Acute abducens nerve palsy following COVID-19 vaccination. Other commonly reported side effects of the Pfizer-BioNTech COVID-19 vaccine include fatigue, headache, and muscle pain. The TGA closely monitors reports of suspected side effects (also known as adverse events) to the Covid-19 vaccines. Keywords: Vaccines and Related Biological Products Advisory Committee December 10, 2020 Meeting Briefing Document FDA. HM, de Oliveira The participants were compared with individuals receiving saline placebo or other vaccines (in case of RCTs) or unvaccinated individuals (in case of observational studies). AA, Doheim 2022 Nov 26;10(33):12289-12294. doi: 10.12998/wjcc.v10.i33.12289. The symptoms also include fatigue, severe headaches, nerve pain, blood pressure swings, and short-term memory problems. 2023 Healthline Media UK Ltd, Brighton, UK. Ann Neurol. Because both subgroups showed high heterogeneity, the leave-1-out analysis was performed, which showed that 1 study42 mainly contributed to the heterogeneity (eFigure 4 in Supplement 1). WT, Huang M, Krasniqi M, Waliszewska-Pros , Goh Before business owner and busy mom Alana Parker experienced severe oral pain and facial swelling after receiving Pfizers COVID-19 vaccine in 2021, she had good dental health with never so much as a cavity. Bell Palsy Events in Groups of mRNA-Vaccinated Participants vs Unvaccinated Participants, With Data From Observational Studies, Figure 3. A. A, Feany An overall 643 records were identified through our systematic search method. , Ab Rahman Neurological symptoms and neuroimaging alterations related with COVID-19 vaccine: cause or coincidence? Administrative, technical, or material support: Yang. XL, Xu , Koh et al. Leave-One-Out Analysis for Observational Studies on mRNA Vaccines: Vaccinated vs Unvaccinated, eFigure 5. They found an increased risk of haemorrhagic stroke, a brain bleed, in the 28 days after vaccination with the BioNTech/Pfizer shot, at an estimated 60 extra cases per 10m people. Bethesda, MD 20894, Web Policies Glob Adv Heal Med. (B) Contrast enhancement in the intracisternal length of the trigeminal nerve (blue arrow). Dashed line indicates the point estimate of the overall effect; dotted line, no effect; diamond, overall effect. Ependymal cells in cerebrospinal fluid: A traumatic occurrence. K, Prasad Misra SJ, Kitchin Clinical features of varicella-zoster virus infection. Involvement of the autonomic nerves, which control involuntary body processes, may lead to: pericarditis and myocarditis, which are inflammation of the outer lining of the heart and inflammation of the heart muscle, respectively, thrombocytopenia syndrome, a condition that causes blood clots to form, a feeling that the heart is pounding, beating fast, or fluttering. April 20, 2023. Neurological adverse events per 1,000,000, Neurological adverse events per 1,000,000 vaccine doses reported in VAERS stratified by COVID, Median age and sex proportions for each adverse event reported in VAERS between, Median time (days) from vaccine injection to adverse event onset, inclusive of all, MeSH Involvement of the motor nerves, which control muscle movement, may produce weakness or muscle cramps. Overall, no publication bias was observed among the studies with the Peter test P value of 0.34 (eFigure 5 in Supplement 1). . Systematic Search Syntax for Databases With Results as of August 15, 2022, eTable 3. The biodistribution (study 514559) also evidenced the vaccine distribution via blood circulation to other tissues notably bone marrow, liver, mammary glands and spleen. Warner CW, Chuang Other neurological side effects occur in a much lower frequency. S, Jawanda MH, The occurrence of BP did not differ significantly between recipients of the Pfizer/BioNTech vs Oxford/AstraZeneca vaccines. This contrasts markedly with the dangers of a severe COVID-19 infection. N, Greenland T, Iwata , Frontera We investigated BP incidence by measuring the pooled effect estimates in the following sets of comparisons: all phase 3 randomized clinical trial (RCT)derived data on vaccine vs saline placebo recipients, messenger RNA (mRNA) SARS-CoV-2 vaccines vs unvaccinated participants in observational studies, Pfizer/BioNTech vs Oxford/AstraZeneca SARS-CoV-2 vaccines, and SARS-CoV-2 infections vs SARS-CoV-2 vaccines. Our search also included review publications, editorials, letters to editors, and conference papers, as well as the references of all the studies included. This stems from rare reports of people experiencing neuropathy symptoms after receiving one of the vaccines. M, Clemens Rosenblum HG, Hadler SC, Moulia D, Shimabukuro TT, Su JR, Tepper NK, Ess KC, Woo EJ, Mba-Jonas A, Alimchandani M, Nair N, Klein NP, Hanson KE, Markowitz LE, Wharton M, McNally VV, Romero JR, Talbot HK, Lee GM, Daley MF, Mbaeyi SA, Oliver SE. VWS, Is the incidence rate of Bell palsy (BP) following SARS-CoV-2 vaccination different from the incidence rate in those who have not received SARS-CoV-2 vaccines? M, Handunnetthi Post-vaccination neurological event rates were compared between vaccine types and to age-matched baseline incidence rates in the U.S. and rates of neurological events following COVID. Bell palsy has also been reported following vaccination,25 although neither a causative relationship nor a prevalence of the condition higher than the general population has been established. Adverse reactions and safety profile of the mRNA COVID-19 vaccines among Asian military personnel. TH. et al. CSL, The data of interest were extracted as follows: (1) study-related variables (first author's name, publication year, sample size, study design, and the presence of control group and its general description); (2) vaccine-related variables, including vaccine type and number of doses received; (3) demographic and baseline variables, including age, sex, past medical history, prior SARS-CoV-2 infection, prior herpes zoster infection, history of BP, and drug history; and (4) clinical and BP-related variables, including number of patients with BP, BP laterality, concomitant signs and symptoms, initial physical examination, duration from vaccination to the event, paraclinical assessments, treatments, outcome, and recurrence if followed up. Please enable it to take advantage of the complete set of features! , Obermann N, A. , Falsey , Egger Single-cell RNA-seq analysis identifies distinct myeloid cells in a case with encephalitis temporally associated with COVID-19 vaccination. The novel COVID-19 vaccines have side effects that require efficient and close monitoring. S, Mooshage However, such an association is confirmed solely in animal studies.108,109 Likewise, the seasonal parenteral inactivated influenza vaccine was shown in the surveys of the VAERS database to have a potential association with BP incidence, as manifested by surveys of the VAERS database.110,111 Monovalent H1N1 influenza vaccines with immunologic adjuvants were also significantly associated with BP.112,113 Similarly, the quadrivalent meningococcal conjugate vaccine was also significantly associated with an increased incidence of BP.114 SARS-CoV-2 vaccines, however, do not contain adjuvants that mediate the immune response. Accessed July 1, 2022. C, Sun , Corra E, Ziaei However, no association between the mRNA vaccines and BP was seen in the observational studies. sharing sensitive information, make sure youre on a federal et al. April 9, 2021. The .gov means its official. The regulatory authorities are, therefore, requested to review the cases of GBS in association with various other neuropathies and vaccine biodistribution data from preclinical trials. Bells palsy after second dose of Moderna covid-19 vaccine: coincidence or causation? This heterogeneity could be attributable to different inclusion criteria or sampling methods. LAQ, Dos Santos Bells palsy following the Ad26.COV2.S COVID-19 vaccination. Y, Beh VK, Peixoto These conditions are called peripheral neuropathies. et al. CC, Sokol performed the risk of bias assessment, and conflicts were resolved via consensus. Some of these conditions affect the peripheral nervous system (PNS), the network of nerves that sends and receives messages to and from the brain and spinal cord. Overall, 13518026 vaccine doses as the vaccinated group were compared with 13510701 matched unvaccinated individuals (Figure 2). Despite this, rates of neurological complications following acute SARS-CoV-2 infection are up to 617-fold higher than after COVID vaccination. , Davidov N, Taneja S, Rcker B, Ann Neurol. The authors declare they have no conflicts of interests. Sixty days later, she had received two doses of the Pfizer COVID-19 vaccine, the first dose on April 10, 2021, and the second dose 21 days later, without any systemic side effects. Is it possible to die from peripheral neuropathy? Headache onset after vaccination against SARS-CoV-2: a systematic literature review and meta-analysis. Online ahead of print. Unauthorized use of these marks is strictly prohibited. N, Doan J, Chan This site needs JavaScript to work properly. Bouattour N, Hdiji O, Sakka S, Fakhfakh E, Moalla K, Daoud S, Farhat N, Damak M, Mhiri C. Neurol Sci. By Michael Levenson. Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in Objective The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. This article is protected by copyright. L, Vuorinen Concept and design: Rafati, Pasebani, Melika Jameie, Mana Jameie, Ilkhani, Amanollahi, Sakhaei, Rahimlou, Kheradmand. The preclinical evaluation of Covid vaccine AZ (study 514559) evidenced vaccine distribution) to various body tissues beyond injection site including sciatic nerves [4]. COVID-19-associated hospitalizations among adults during SARS-CoV-2 Delta and Omicron variant predominance, by race/ethnicity and vaccination statusCOVID-NET, 14 states, July 2021-January 2022. The .gov means its official. MNT is the registered trade mark of Healthline Media. WebCOVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given; Fever; Fatigue; Headache; Muscle pain; C, Vazquez-Feito N, Miyazaki The study was exempt from ethical approval by the local institutional ethics committee because we used previously published data. OR indicates odds ratio; SIDIAP, Spanish database of Information System for Research in Primary Care. et al. A persons symptoms, if they have any, could depend on the type of nerves that have the damage. O, Y, Tsaraf et al; Cochrane Bias Methods Group; Cochrane Statistical Methods Group. M, Mansourabadi In rare cases, serious side effects occur. N, Nayak , Poudel Therefore, further research using larger-scale studies is necessary to determine the link between COVID-19 vaccines and peripheral neuropathy. Involvement of sensory nerves, which control temperature and the sense of touch, may result in: an inability to feel a change in temperature or pain, a loss of position sense of body parts, which can cause a lack of coordination. T. Thereafter, 463 records were screened by title and abstract, and 84 remained for further evaluation. July 2, 2022. M, et al. For the analysis from the study by Li et al,57 only the data obtained from the Spanish database of Information System for Research in Primary Care were used for data pooling, and the data from the UK were excluded because of database overlapping with the study by Patone et al.56 The odds of developing BP after receipt of the Pfizer/BioNTech vaccine compared with the Oxford/AstraZeneca vaccine were deemed insignificant (OR, 0.97; 95% CI, 0.82-1.15; I2=0%; Cochran Q P value=.67). This study followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).31 The study protocol has been registered with PROSPERO (CRD42022313299). AH, To address this issue, we conducted a systematic review and meta-analysis of studies reporting BP following SARS-CoV-2 vaccination to examine whether SARS-CoV-2 vaccination is associated with a higher incidence of BP compared with unvaccinated or placebo-vaccinated individuals. The quality of the studies was evaluated by the Newcastle-Ottawa Scale. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and was conducted with the random- and fixed-effect models using the Mantel-Haenszel method. SJ, Moreira JA, Tamborska 2023 Feb;12(2):338-351. doi: 10.4103/jfmpc.jfmpc_1574_22. V, Marttila , Peters [4] https://assets.publishing.service.gov.uk/government/uploads/system/uploa [5] https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-ho FTT, Huang P, Awasthi Safety of quadrivalent meningococcal conjugate vaccine in 11- to 21-year-olds. Bells palsy: diagnosis and management. Notably, SARS-CoV-2 infection was linked with a 3.23-fold increased risk of BP compared with SARS-CoV-2 vaccines, which favors a protective role of the vaccine in reducing the incidence of BP associated with exposure to SARS-CoV-2. Is the incidence rate of Bell palsy (BP) following SARS-CoV-2 vaccination different from the incidence rate in those who have not received SARS-CoV-2 vaccines? R, Hukkanen , Page F, Tatsi -. PRISMA Flow Diagram of the Systematic Search, eFigure 2. Front Pharmacol. , Hanson Inflammation Facial nerve palsy after COVID-19 vaccinationa rare association or a coincidence. T, Niimi J Korean Med Sci. V, Michos The occurrence of BP did not differ between recipients of the Pfizer/BioNTech and Oxford/AstraZeneca vaccines, and there was a greater risk of BP with SARS-CoV-2 infection compared with SARS-CoV-2 vaccination. , Taylor HHS Vulnerability Disclosure, Help The meta-analysis was composed of 2 subgroups of mRNA vaccines (Pfizer/BioNTech and Moderna) and viral vector vaccines (Janssen and Oxford/AstraZeneca) (Figure 1). Vaccines and Related Biological Products Advisory Committee meeting December 10, 2020. Bells palsy following COVID-19 vaccination. Considerations for causality assessment of neurological and neuropsychiatric complications of SARSCoV2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder. (C) The contrast enhancement of the facial nerve persists upon repeated examination a month later (blue arrow). Woo EJ, Mba-Jonas A, Dimova RB, Alimchandani M, Zinderman CE, Nair N. JAMA. A, Maung Another condition of the PNS that may have associations with the COVID-19 vaccine is small fiber neuropathy. The most commonly reported symptoms of post- COVID-19 syndrome include: Fatigue Symptoms that get worse after physical or mental effort Fever Lung (respiratory) symptoms, including difficulty breathing or shortness of breath and cough Other possible symptoms include: Intramuscular route (Suspension) Although the licensed vaccine (Comirnaty) is FDA-approved in patients aged 16 or older for 2 doses , Pfizer-BioNTech eCollection 2023. contributors from the Global COVID-19 Neuro Research Coalition, See this image and copyright information in PMC. S. Bells palsy after inactivated COVID-19 vaccination in a patient with history of recurrent Bells palsy: a case report. N, Ben-Shlomo PMC Association of SARS-CoV-2 Vaccination or Infection With Bell Palsy: A Systematic Review and Meta-analysis. M, Baharlouie This study shows evidence for the association between SARS-CoV-2 and BP; however, this finding does not equate to causality, and further research is required to verify this association and investigate possible mechanisms. A, Gonzalez-Gimeno RMM, Alswat S, Ish World Health Organization. The Egger and Peter tests both yielded nonsignificant results; hence, no publication bias was detected. LS, Chen Etiology of aseptic meningitis and encephalitis in an adult population. Drafting of the manuscript: Rafati, Pasebani, Melika Jameie, Yang, Mana Jameie, Ilkhani, Amanollahi, Sakhaei, Kheradmand. W, Rhodes When attempting to compare with other vaccines and diseases, SARS-CoV-2 vaccine studies did not provide sufficient data for pooling. , Lim 2021 John Wiley & Sons A/S. 8600 Rockville Pike et al. Experts have said hearing loss can be caused by the immune system's inflammatory response to fight a illness, drugs to treat the illness or cell damage. Y, Toda The MHRA pharmacovigilance database reported ~187 cases of sciatica post-Covid vaccine AZ as of 28th July 2021. Significantly more neurological adverse events were reported following Janssen (Ad26.COV2.S) vaccination compared to either Pfizer-BioNtech (BNT162b2) or Moderna (mRNA-1273; 0.15% versus 0.03% versus 0.03% of doses, respectively,P<0.0001). et al; C4591001 Clinical Trial Group. It is worth noting that the Covid vaccine AZ clinical trials were paused twice and, on both occasions, the trial subjects developed a neurological condition, transverse myelitis. AA. The CDC does not list brain aneurysms as a common side effect after COVID-19 vaccination in any age group. 2021 Oct 26;326(16):1606-1613. doi: 10.1001/jama.2021.16496. Before Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nath is convinced they are extremely rare. Long Covid, in contrast, affects anywhere from about 5% G, Schwarzer Importantly, although this study shows evidence of increased BP incidence following SARS-CoV-2 vaccination compared with placebo receipt, SARS-CoV-2 infection was associated with a 3.23-fold increase in BP incidence. , Polack The risk of developing BP subsequent to SARS-CoV-2 infection significantly surpassed the risk of developing BP after receipt of the SARS-CoV-2 vaccine (RR, 3.23; 95% CI, 1.57-6.62; I2=95%; Cochran Q P value<.001). Most importantly, we used previously published data, and no individual patient-level data were available in this study. Evaluation of prognostic factors in patients with Bells palsy. eTable 1. WebLocal reactions in persons aged 511 years, Pfizer-BioNTech COVID-19 vaccine and placebo a Mild: >2.0 to 5.0 cm; moderate: >5.0 to 10.0 cm; severe: >10.0 cm; Grade 4: necrosis Additionally, the vaccines met the strict safety standards of the FDA. Bells palsy and SARS-CoV-2 vaccines. Three studies94-96 met the inclusion criteria; however, they used the same patient databases, hence overlapping considerably with the included studies from Hong Kong. One proposed mechanism is nerve compression within the temporal bone due to the perineural inflammation and subsequent edematous nerve bundles in response to viral infections,102 such as herpes zoster, varicella zoster,60 or Epstein-Barr viruses.103 These neurotropic viruses are also reportedly associated with neurologic complications, such as GBS, neuropathies, olfactory dysfunction, aseptic meningitis, and encephalitis.104-106 Similarly, vaccination has been a crucial means to reduce this overwhelming burden of viral infections for these viruses. et al. Association of COVID-19 vaccination and facial nerve palsy: a case-control study. Quality Assessment of the Cross-Sectional Studies Using the Newcastle-Ottawa Scale (NOS) Modified for Cross-Sectional Studies, eTable 7. WHO coronavirus (COVID-19) dashboard. Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong. SARS-CoV-2 infection posed a significantly greater risk for BP than SARS-CoV-2 vaccination. Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series. To examine whether the Pfizer-BioNTech vaccine is associated with multiple cranial neuropathy. To compare the incidence of BP in SARS-CoV-2 vaccine recipients vs unvaccinated individuals or placebo recipients. More discrete side effects connected to COVID-19 vaccines have been recognized, including a rare but severe clotting disorder that occurs after the AstraZeneca There may be a connection between peripheral neuropathy and the COVID-19 vaccine. K, Watanabe , Tseng , Burrows 2023 Apr 27:e230160. The Egger test yielded a P value of .64; hence, no publication bias was present. Summary of the Studies Characteristics (Case Reports and Case Series), eTable 4. Unable to load your collection due to an error, Unable to load your delegates due to an error, Images were acquired by use of T1weighted, contrastenhanced MPRAGE TRA ISO sequences, in the axial plane. Dashed line indicates the point estimate of the overall effect; dotted line, no effect; diamonds, overall effects. 2023 Feb 23;14:998233. doi: 10.3389/fimmu.2023.998233. A 32-year-old psychologist in Britain developed blood clots and died 10 days after he took his first dose of AstraZenecas Covid , Sadeghalvad Warning. Individuals over the age of 65 can receive a second updated COVID-19 vaccineeither Pfizer or Moderna at least four months after their last updated dose. CKH, Au Would you like email updates of new search results? 2021 Oct;25(5):302-303. doi: 10.1016/j.jaapos.2021.05.003. M, Yokota How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, The link between peripheral neuropathy and the COVID vaccine, Disorders of the PNS associated with COVID vaccine, Centers for Disease Control and Prevention (CDC), https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707152/, https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-july-13-2021?utm_medium=email&utm_source=govdelivery, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety.html, https://journals.lww.com/jfmpc/fulltext/2022/07000/small_fiber_neuropathy_as_a_complication_of.120.aspx, https://www.cdc.gov/vaccinesafety/concerns/guillain-barre-syndrome.html, https://www.ninds.nih.gov/health-information/disorders/peripheral-neuropathy, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780646/, https://www.fda.gov/media/144245/download, https://www.hematology.org/covid-19/vaccine-induced-immune-thrombotic-thrombocytopenia, New clues to slow aging? Significance was set at, Median age and sex proportions for each adverse event reported in VAERS between January 1, 2021June 14, 2021, inclusive of all COVID vaccine brands. Addressing the publication bias, the funnel plots are provided in eFigure 3 in Supplement 1. Reuters, "COVID vaccine injury plaintiffs face long odds in U.S. compensation program," June 16, 2022 Federal Aviation Administration statements, April 27 and April 28, 2023 VP. government site. Corresponding Authors: Amir Kheradmand, MD, Department of Neurology, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Path 2-210, Baltimore, MD 21287 (akherad@jhu.edu); Mehran Rahimlou, PhD, Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran (rahimlum@gmail.com). et al. and transmitted securely. JH. , Hls doi: 10.3346/jkms.2023.38.e95. Thus, our results suggest that vaccinating against SARS-CoV-2 can significantly diminish the odds of BP compared with SARS-CoV-2 infection. 8600 Rockville Pike , Martin-Villares Epub 2023 Feb 28. LE, JAMA Otolaryngol Head Neck Surg. Online ahead of print. DR, Thakur Of the excluded studies, 3 records91-93 were the reports of preliminary results of the major SARS-CoV-2 vaccine phase 3 clinical trials, of which the records reporting the final analyses were included instead. P, Moghadas Reuters, "COVID vaccine injury plaintiffs face long odds in U.S. compensation program," June 16, 2022 Federal Aviation Administration statements, April 27 and April 28, 2023 doi: 10.1136/bcr-2021-243829. Three of the 5 RCTs had a low risk of bias,35-37 and 2 were unclear38,58 in the criterion D5: detection bias of the Cochrane assessment tool but were low risk in the rest of the criteria. Epub 2021 Nov 29. , Li et al. These vaccines included Moderna and Pfizer/BioNTech among patients 12 years or older. [8] https://assets.publishing.service.gov.uk/government/uploads/system/uploa S, Funnel Plot for RCTs: vaccinated vs saline placebo, eFigure 4. L. Impact of COVID-19 vaccines on the health status of young female adults from India: A cross-sectional study. MJ, Hutchison et al. BK, [11] https://onlinelibrary.wiley.com/doi/10.1111/ncn3.12537, Competing interests: FTT, Chua Would you like email updates of new search results? 2023 Apr 18:S1043-2760(23)00055-3. doi: 10.1016/j.tem.2023.03.002. ED Reports of serious neurological events following COVID vaccination are rare. M, Sobherakhshankhah I. M, A potential signal of Bells palsy after parenteral inactivated influenza vaccines: reports to the Vaccine Adverse Event Reporting System (VAERS)United States, 1991-2001. With a high heterogeneity, a random-effects model was used, and a leave-1-out analysis was performed, which showed that 1 study57 mainly contributed to the heterogeneity (eFigure 7 in Supplement 1). Some information may be out of date. CO, da Cruz Final analysis of efficacy and safety of single-dose Ad26.COV2.S. Bells palsy following COVID-19 vaccine administration in HIV+ patient. By July 13, 2021, healthcare professionals had administered 12.5 million vaccine doses and reported only 100 cases of GBS. Bell palsy (BP) has been reported as an adverse event following the SARS-CoV-2 vaccination, but neither a causative relationship nor a higher prevalence than in the general population has been established. MA. It isn't clear how long these effects might last. F, Zhao Notably, none of the studies had any data from children younger than 12 years, and this inclusion bias impedes the generalizability of the findings to this younger age range. K, Mano et al. After removing duplicate records, 2 independent researchers (Y.P. doi: 10.1001/jamaoto.2023.0160. Likewise, the case-control studies39,40 yielded a nonsignificant result (OR, 1.37; 95% CI, 0.64-2.90; I2=54%; Cochran Q P value=.14).

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